![]() ![]() The various antimicrobial and cytotoxic compounds contained in granules can destroy malignant cells, and cytokines and chemokines secreted by neutrophils can also recruit other cells with antitumor activity. Indeed, neutrophils may be potent antitumor effector cells. This renewed interest comes in part from the recognition that cancer-related inflammation is an important feature for the development of many tumors and it is a hallmark of cancer. ![]() However, more recently it is becoming clear that TANs have relevant roles in malignant disease. Early studies suggested that these tumor-associated neutrophils (TANs) were mere bystanders because it was hard to imagine that neutrophils, being short-lived cells, could have an effect on chronic and progressive diseases such as cancer. īesides this classical role in antimicrobial functions, neutrophils are also found infiltrating many types of tumors. In addition, neutrophils are capable of producing many cytokines and chemokines, which can influence the inflammatory response, as well as the immune response. Activated neutrophils also release proteinases into the surrounding tissue, causing damage to the host. There, neutrophils destroy the microorganism by a series of mechanisms, mainly phagocytosis, release of antimicrobial substances, and the formation of neutrophil extracellular traps (NETs). Invading microorganisms evoke an inflammatory response that recruits neutrophils from the circulation into the tissues. Neutrophils are the most abundant leukocytes in blood and are considered to be the first line of defense during inflammation and infections.
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